Novel associations of UDP-glucuronosyltransferase 2B gene variants with prostate cancer risk in a multiethnic study
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چکیده
منابع مشابه
the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولA polymorphism in the UDP-Glucuronosyltransferase 2B15 gene (D85Y) is not associated with prostate cancer risk.
Introduction UGT, a family of Phase II detoxification enzymes, catalyzes the transfer of the glucuronyl group from uridine diphosphogluronic acid to many substrates, including steroid hormones (1). Glucuronidation, an irreversible step in the pathway of steroid metabolism, converts steroids into polar, water soluble derivatives and may alter the levels of active androgens in steroid target tiss...
متن کاملNull Results in Brief A Polymorphism in the UDP-Glucuronosyltransferase 2B15 Gene (DY) Is Not Associated with Prostate Cancer Risk
Introduction UGT, a family of Phase II detoxification enzymes, catalyzes the transfer of the glucuronyl group from uridine diphosphogluronic acid to many substrates, including steroid hormones (1). Glucuronidation, an irreversible step in the pathway of steroid metabolism, converts steroids into polar, water soluble derivatives and may alter the levels of active androgens in steroid target tiss...
متن کاملA large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.
UNLABELLED A genome-wide association study (GWAS) of prostate cancer in Kaiser Permanente health plan members (7,783 cases, 38,595 controls; 80.3% non-Hispanic white, 4.9% African-American, 7.0% East Asian, and 7.8% Latino) revealed a new independent risk indel rs4646284 at the previously identified locus 6q25.3 that replicated in PEGASUS (N = 7,539) and the Multiethnic Cohort (N = 4,679) with ...
متن کاملAssociation Study of miR-124-a-3 Gene rs34059726 Polymorphism with Prostate Cancer in Gonbad Kavous
Background: MiRNAs are one of the most important genetic regulators that regulate more than 50 percent of the human genome. MiR-124-a-3 is a tumor suppressor miRNA which its expression dramatically reduced in prostate cancer tumor cells. Since miRNA binding to the transcript of target genes by seed sequence, any mutations and changes in this region could be effective on its performance and iden...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2013
ISSN: 1471-2407
DOI: 10.1186/1471-2407-13-556